Patient related risks for mace in the perioperative period are pre existing ischemic coronary disease systolic and diastolic heart failure male gender diabetes renal insufficiency and age greater than 65 years with an exponential increase in risk after age 8550 nonetheless undergoing anesthesia is 97 safer now than it was prior to 1953 . Anesthesia and perioperative complications article in german merk h1 forst h author information 1klinik fur anasthesiologie und operative intensivmedizin zentralklinikum augsburg zkanaforstt onlinede pmid 10928262 indexed for medline publication types review mesh terms anesthesia humans intraoperative complications. Anesthesia perioperative complications publication date 1999 topics complications of drugs used in anesthesia perioperative nerve injury why monitoring during anesthesia has unintended and undesirable consequences the causes and consequences of impaired gas exchange causes and consequences of arrhythmias hypotension . Anesthesia perioperative complications hardcover august 31 1999 by jonathan l benumof md author lawrence j saidman md author 50 out of 5 stars 2 ratings comprehensive scholarly and clinically relevant anesthesia and perioperative complications is a complete reference on the complications of anesthesia part i complications