Furthermore clinical pharmacologists consider anti epi leptic drugs as model drugs in pharmacokinetics and pharmocodynamics since reliable methods are available for their determination and their effects and side effects can be defined the methods of estimating of drugs in body fluids provide a tool that enables us to throw light on many obscure relationships in pharmaceutical treatment . Despite the availability of newer agents a number of antiepileptic drugs have continued to be employed reasonably widely many years after their introduction to human therapeutics these drugs comprise phenobarbitone and some of its congeners phenytoin ethosuximide carbamazepine valproate and certain benzodiazepines. Clinical pharmacology of anti epileptic drugs workshop on the determination of anti epileptic drugs in body fluid ii wodadibof ii held in bethel bielefeld germany 24 25 may 1974 englisch taschenbuch 1 januar 1975 von h schneider herausgeber d janz series editor. This article illustrates basic principles of clinical pharmacology presented in article 1 with specific examples from the treatment of seizure disorders the discussion includes protein binding the role of a major carbamazepine metabolite alterations in pharmacology of aeds in the elderly and aed withdrawal the last topic in particular is a good example of the interaction of
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