Malaria molecular and clinical aspects amazonde wahlgren mats perlmann peter stockholm university sweden bucher wahlen sie ihre cookie einstellungen wir verwenden cookies und ahnliche tools um ihr einkaufserlebnis zu verbessern um unsere dienste anzubieten um zu verstehen wie die kunden unsere dienste nutzen damit wir verbesserungen vornehmen konnen und um werbung anzuzeigen. Malaria glycosylphosphatidylinositol gpi and hemozoin two well recognized malaria toxins are plasmodium pathogen associated molecular patterns pamps that have been shown to be recognized by toll like receptors tlrs a class of animal specific receptor proteins with variable extra cellular leucine rich repeats expressed by cells of the innate immune system that stimulate a proinflammatory response when activated by non self ligands . Although clinically benign malaria fever is thought to have significant relevance in terms of parasite growth and survival and its virulence which in turn may alter the clinical course of illness in this article the historical literature is reviewed providing some evolutionary perspective on the genesis and biological relevance of malaria fever and the available molecular data on the febrile temperature inducible parasite factors that may contribute towards the regulation of parasite . Malaria causes more death and disease than any other parasitic pathogen known today this multiauthored text covers the important areas of malaria research particularly focusing on those sectors which are of clinical importance for the understanding of the disease the parasite and its vector. Although clinically benign malaria fever is thought to have significant relevance in terms of parasite growth and survival and its virulence which in turn may alter the clinical course of illness in this article the historical literature is reviewed providing some evolutionary perspective on the genesis and biological relevance of malaria fever and the available molecular data on the